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The shooting followed a deadly Israeli raid in the occupied West Bank on Thursday at the Jenin refugee camp in which nine Palestinians were killed.
An armed man opened fire and killed at least five people near a synagogue in East Jerusalem before being shot dead, according to Israeli doctors.
After Friday’s shooting, the Magen David Adom emergency service said it was treating 10 injured people, some of them in critical condition.
Israeli police said the shooter was shot dead on the spot.
“We understand that a car stopped in front of the synagogue, an armed man got out and opened fire,” Al Jazeera correspondent James Bays said in East Jerusalem.
“Israeli health officials say five people have died. Some media reports that this figure may be higher – up to seven killed. The information is quite confusing.”
A police statement said that there was “a terrorist attack at a synagogue in Jerusalem… The terrorist who shot him was neutralized on the spot. A large police force is on the scene.”
The attack follows a deadly Israeli raid in the occupied West Bank on Thursday at the Jenin refugee camp. Nine Palestinians, including an elderly woman, were killed after dozens of Israeli soldiers attacked a house containing suspected militants, leading to several hours of heavy fighting.
The Gaza militants then fired rockets and Israel launched air strikes at night, but the exchange was limited.
Israeli military raids have become a regular occurrence over the past year, with at least 200 Palestinian militants and civilians killed.
Israeli civilians and soldiers have also been killed in Palestinian attacks in Israel and the occupied territories.
Friday’s shooting came amid heightened tensions. Palestinians marched in anger, burying the last Palestinians killed by Israeli forces the day before.
Clashes between Israeli forces and Palestinian protesters erupted after the funeral of a 22-year-old Palestinian north of Jerusalem and elsewhere in the occupied West Bank.
Crowds of Palestinians waved the flags of both Fatah, the party that controls the Palestinian Authority, and Hamas, which rules Gaza. On the streets of a city called Al-Ram, masked Palestinians threw stones and fireworks at Israeli police, who responded with tear gas.
Israeli opposition leader and former Prime Minister Yair Lapid called Friday’s attack “terrifying and heartbreaking.”
